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Align · ED comparison · 8 min read
Tadalafil 10, sildenafil 25-50, and vardenafil 20 compared on clocks and cash
Medically reviewed by Dr. Mateo Ruiz, MD - Clinical pharmacology, Barcelona
Last reviewed
Updated
01Three strengths, three separate price tables
Search results tend to blend Cialis, Viagra, and Levitra into a single ED pill price, then quote a per-tablet average that never appeared on any label. This sheet refuses that mash. tadalafil 10 mg as needed, sildenafil 25 mg or 50 mg, and vardenafil 20 mg. Other strengths exist. They are not priced here.
GoodRx tablet tables list generic tadalafil 10 mg x 30 at $2,172.94 average retail and $18.77 with a coupon; generic sildenafil 25 mg x 10 at $67.14 / $13.53 and 50 mg x 10 at $646.10 / $11.35; generic vardenafil 20 mg x 10 at $573.78 / $44.21 (06 July 2026 for the Levitra table). Those are pack prices, not a checkout on qivanarx.com.
Dr. Mateo Ruiz reviewed this comparison in Barcelona on 21 August 2026. The page is educational. [email protected] takes source corrections, not dose requests. Read the tadalafil, sildenafil, and vardenafil pages for the full pharmacology.
02One nitrate wall, three different clocks
Organic nitrates and riociguat are contraindicated with all three. Tadalafil's longer half-life lengthens the interval before anyone even considers a nitrate in an emergency setting. Sildenafil and vardenafil have shorter tails.
Food is almost flat for tadalafil 10 mg, costly for sildenafil 25-50 mg, and mixed for vardenafil 20 mg. Alcohol adds hypotension on every row.
Priapism past four hours, sudden monocular vision loss, and sudden hearing drop stop every INN. A prettier coupon does not change the phone number.
Clocks from US labels, not from a blended per-tablet average
Clock
Tadalafil 10 mg PRN
Sildenafil 25-50 mg
Vardenafil 20 mg
Usual labelled start
10 mg as needed
50 mg (25 mg when rows say so)
10 mg; 20 is the ceiling
Food
With or without meals
High-fat: later, lower Cmax
High-fat can cut Cmax
Counselling window
Trials to 36 h
Often ~4 h
Shorter than tadalafil
Special footnote
Renal/CYP caps on 10 mg
Ritonavir: 25 mg / 48 h
QT avoid list
03Ritonavir and other CYP3A4 caps wreck coupon shopping
Sildenafil: 25 mg not more than once every 48 hours. Tadalafil as needed: 10 mg not more than once every 72 hours. Vardenafil: 2.5 mg in 72 hours on the strong-inhibitor row. A pharmacy pricing vardenafil 20 mg by ten for someone on ritonavir is pricing the wrong strength.
Ketoconazole and itraconazole pull the same lever with different caps. Bring the full list. Do not ask this site to choose an INN from a coupon column.
04What a tadalafil 10 mg thirty-count actually costs
Thirty generic tadalafil 10 mg tablets is the strength and quantity this page prices. The Cialis label starts most as-needed patients at 10 mg, then allows a move to 20 mg or down to 5 mg. Food does not steer absorption. Erectile function in the as-needed trials stayed above placebo out to 36 hours.
The cash shock is the retail column: $2,172.94 for that thirty-count before a coupon collapses it to $18.77. If the pharmacist hears Cialis and enters a 20 mg thirty-count, you are no longer pricing the same product. Daily 2.5 mg and 5 mg bottles are a different rhythm and a different GoodRx row.
Per-tablet coupon math from $18.77 / 30 is about sixty-three cents. That number is useful only after the count is right. If the real question is Friday-to-Sunday coverage, read the 36-hour timing note.
One strength and one count per drug. GoodRx Cialis, sildenafil, and Levitra tablet tables; vardenafil 20 x 10 marked 06 July 2026. This site does not dispense. Prescription required.
Medicine and strength
Count on the board
GoodRx retail
GoodRx coupon
Tadalafil 10 mg PRN (Cialis generic)
30 tablets
$2,172.94
$18.77
Sildenafil 25 mg (Viagra generic)
10 tablets
$67.14
$13.53
Sildenafil 50 mg (Viagra generic)
10 tablets
$646.10
$11.35
Vardenafil 20 mg (Levitra generic)
10 tablets
$573.78
$44.21
05Vardenafil 20 mg by ten is a ceiling pack, not a start pack
Levitra film tablets start most men at 10 mg. Twenty milligrams is the labelled maximum. GoodRx lists generic 20 mg x 10 at $573.78 / $44.21 (06 July 2026). Staxyn ODT is a different product.
QT language comes before the coupon. Class IA and Class III antiarrhythmics and congenital long QT sit on the avoid list. The QT note holds that row. Peak time sits near 60 minutes fasted; high-fat meals can cut Cmax 18 to 50 percent.
06Sildenafil 25 mg and 50 mg by ten are two different prices
Pfizer's Viagra label still starts most men at 50 mg about an hour before activity, with a window from 30 minutes to 4 hours, and allows a step to 25 mg or a ceiling of 100 mg once per day. This page prices the first two strengths. The 100 mg maximum is described on the sildenafil page and not priced here.
The 25 mg ten-count prints $67.14 / $13.53. The 50 mg ten-count prints $646.10 / $11.35. Retail on 50 mg is not 'twice 25 mg.' Coupon on 50 mg can undercut coupon on 25 mg. Men who pick 25 mg to save money sometimes pay more per successful dose if 25 mg was never going to be enough.
High-fat meals delay the peak by about an hour and cut Cmax about 29 percent at both 25 and 50 mg. The 25 versus 50 mg note is the step page.
07Pay for one strength at one count
Keep the nitrate wall. Skip the heavy meal if sildenafil is the plan. Skip Levitra 20 when the QT list is dirty. Then read the page for that single drug rather than adding a second one.
The 21 August 2026 date is an editorial review date. GoodRx figures change. If the leaflet in the box disagrees with a row here, follow the leaflet and send the source to [email protected].
Most price questions that reach [email protected] share one mistake: readers treat a Cialis 10 mg coupon, a Viagra 25-50 mg listing, and a Levitra 20 mg quote as parts of the same purchase. They are three NDCs with three clocks. Dr. Mateo Ruiz answers when a reader wants two different PDE5 inhibitors for one weekend. Chest pain on a nitrate, an erection past four hours, or sudden vision loss means stop every PDE5 tablet and call emergency services. This site does not dispense.
Tomas W. Can I order Cialis 10, Viagra 25, and Levitra 20 on one weekend script?
Vault reply
No. No PDE5 label supports taking two of these drugs in the same dosing period. Tadalafil 10 mg still has a 17.5-hour half-life; Sunday sildenafil or vardenafil rides on leftover exposure. Hypotension and headache rise. Erection scores do not add. Pick one drug at one strength, give it four to six proper attempts, then adjust that dose or discuss a switch. The 36-hour timing note explains Friday-to-Sunday coverage on 10 mg. It is not permission to add sildenafil in the gap.
Imani R. Why is tadalafil 10 x 30 retail over two thousand if the coupon is $18.77?
Vault reply
Because the GoodRx Cialis tablet table prints two numbers for the same thirty-count: average retail $2,172.94 and a coupon print $18.77. The retail column is what cash walk-up often meets before a discount card. Neither figure is payable on this site. Ask a licensed pharmacy to price generic tadalafil 10 mg, thirty tablets. Daily 2.5 mg and as-needed 20 mg packs are priced separately.
Sergei M. Is Viagra 25 cheaper than 50 because it is half the milligrams?
Vault reply
Not on the price tables this page uses. GoodRx lists generic sildenafil 25 mg x 10 at $67.14 retail / $13.53 coupon, and 50 mg x 10 at $646.10 / $11.35. The 50 mg retail column is almost ten times the 25 mg retail. The coupons sit near each other. You pick 25 mg when the label says start there - age, liver, severe kidney, alpha-blockers, or ritonavir - not because the coupon looks friendlier. See the sildenafil page.
Gisela P. Levitra 20 coupon is $44.21 and tadalafil 10 coupon is $18.77 - why not always take tadalafil?
Vault reply
Because $18.77 buys thirty tadalafil 10 mg tablets and $44.21 buys ten vardenafil 20 mg tablets. Per-tablet coupon math is about $0.63 versus $4.42, but the clocks are not in the price. Tadalafil 10 mg is the as-needed starting dose, with a response period that can reach 36 hours and almost no food effect. Vardenafil 20 is the labelled ceiling, not the start (the start is 10 mg), with a shorter tail and a QT footnote. If you have congenital QT prolongation or take quinidine, procainamide, amiodarone, or sotalol, the tadalafil coupon is beside the point: vardenafil 20 mg is off the table.
Yusuf K. Can I get these cheaper from an overseas site than a US pharmacy?
Vault reply
This site has no checkout. Imported blisters that look cheaper often come in a different quantity, arrive without counselling, and sometimes do not hold the active ingredient you think you bought. A US pharmacy still needs a prescription. Ask the window to price exactly what the prescription says: tadalafil 10 mg by thirty, sildenafil 25 or 50 mg by ten, or vardenafil 20 mg by ten.
Britt S. Generic versus brand at the same strength - does the coupon still apply?
Vault reply
A tadalafil 10 mg generic has to match Cialis 10 mg for that INN. A sildenafil 25 or 50 mg generic has to match Viagra at that strength. A vardenafil 20 mg generic has to match Levitra 20 mg. That is substitution inside one INN, not a hop from Cialis to Levitra because the coupon is prettier. Brand tablets cost far more than the generic figures quoted here; this page does not invent a brand number. The fatty-meal note still applies to generic sildenafil 25 and 50 mg.
Andres V. I have a nitro spray. Does a generic change the nitrate rule?
Vault reply
No. Organic nitrates and riociguat stay contraindicated with tadalafil, sildenafil, and vardenafil whether the tablet cost $0.63 or $70. Tadalafil's 17.5-hour half-life lengthens the nitrate-free interval after the last 10 mg dose compared with the shorter sildenafil and vardenafil tails. Poppers follow the same pathway. Chest pain during intimacy is a cardiac visit, not a second PDE5 tablet.
Keiko N. Restaurant dates every week - which tablet still makes sense?
Vault reply
High-fat meals delay sildenafil Tmax by about 60 minutes and cut Cmax about 29 percent. That applies to 25 mg and 50 mg equally. Tadalafil 10 mg may be taken without regard to food. Vardenafil 20 mg can be taken with or without food, but high-fat meals can still drop Cmax. If every evening involves a heavy meal and wine, do not buy sildenafil hoping 50 mg will push through the fat. Alcohol is a separate hypotensive layer on all three.
Pavel D. I take amiodarone. Is the Levitra 20 price even relevant?
Vault reply
The price is irrelevant until the QT screen is clean. Patients with congenital QT prolongation or on Class IA or Class III antiarrhythmics should avoid vardenafil. Amiodarone sits in that Class III group. A $44.21 coupon does not buy a pass. The vardenafil page and the QT note keep that warning visible. Do not switch to tadalafil 10 mg at the counter just because an insurer rejected the vardenafil claim.
Noemi L. Ritonavir on my HIV regimen - which coupon can I even use?
Vault reply
Ritonavir changes every dose in this class. Sildenafil: do not exceed 25 mg in 48 hours, which makes the 50 mg strength on this page wrong for that patient. Tadalafil as needed: a maximum of 10 mg once every 72 hours. Vardenafil: a single 2.5 mg dose in 72 hours, so 20 mg is not that patient's tablet at all. Bring the full antiviral list, not a coupon screenshot. Dr. Ruiz does not adjust antiretroviral therapy by email.
Before you start, stop, or change any medicine, speak with your prescriber or pharmacist - they hold your chart, this vault card does not. Open the vault disclaimer.
