QivanaRx Glow Lab

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Probe · vardenafil · 3 min read

Can Levitra 20 mg be used if the liver is severely impaired?

No. Child-Pugh C closes Levitra. Vardenafil has not been evaluated in severe hepatic impairment. Child-Pugh B starts at 5 mg and must not exceed 10 mg. After a 10 mg dose in moderate impairment, Cmax was 130 percent higher and AUC 160 percent higher than in healthy controls. Child-Pugh A raised Cmax 22 percent and AUC 17 percent; no dose cut is written there. This vault's 20 mg lock is the ordinary ceiling, not a hepatic tablet.

Medically reviewed by Dr. Mateo Ruiz, MD - Clinical pharmacology, Barcelona

Last reviewed

Updated

01What does the insert say at Child-Pugh C?

Forest-green still life: liver-shaped stone, empty space where a tablet is missing

Do not use Levitra in patients with severe hepatic impairment (Child-Pugh C). The drug has not been evaluated in that group. Twenty milligrams does not create a missing study.

A shop that never asks about the liver is incomplete. This page will not reopen Child-Pugh C with a ceiling pack.

02What if ketoconazole sits on a Child-Pugh B chart?

Moderate impairment already caps at 10 mg. Strong CYP3A4 inhibitors force 2.5 mg. The tighter row wins. Twenty milligrams is not the tie-breaker.

The CYP probe holds ritonavir's 72-hour gap. Bring both the liver grade and the inhibitor to the visit that writes the first strength.

03Why does this site still lock 20 mg if the liver can close it?

The 20 mg lock is the ordinary labelled maximum after a 10 mg start in men whose liver row is open. Hepatic C is a closed door. Hepatic B never reaches 20 mg.

Read the vardenafil 20 mg vault for the ceiling tablet when the liver row is clean. Read this probe when it is not.

04Does mild impairment change the milligram?

Mild hepatic impairment after 10 mg raised Cmax 22 percent and AUC 17 percent versus healthy controls. No dosage adjustment is necessary in mild hepatic impairment.

Mild impairment is not a reason to skip the 10 mg usual start for most men. It is also not a reason to invent a 20 mg requirement.

05What is written at Child-Pugh B?

Moderate impairment opens at 5 mg and stops at 10 mg. In volunteers with moderate impairment, Cmax and AUC after 10 mg were increased by 130 percent and 160 percent versus healthy controls.

Those exposure jumps are why 20 mg is off the moderate chart. A 20 mg first night in Child-Pugh B is the cart talking.

06Is dialysis the same closed door?

Do not use Levitra in patients on renal dialysis. Vardenafil has not been evaluated there. Dialysis is not expected to pull the drug off anyway: it is highly protein-bound and little is eliminated in urine.

Creatinine clearance down to below 30 mL/min raised AUC only 20 to 30 percent in volunteers. That renal row is not Child-Pugh C. Do not mix the two organs.

Sources

  1. DailyMed LEVITRA (vardenafil)
  2. LEVITRA 2.3 / 8.6 / 12.3: Child-Pugh B Cmax +130%, AUC +160% after 10 mg; Child-Pugh C do not use.

Checked against the current label and reviewed by Dr. Mateo Ruiz. See Probe, Assay, Glow-check, Seal.

Vault consult

Answers follow the U.S. Levitra label.

Quinn A. Cirrhosis, Child-Pugh C. Weekend 20 mg?

Vault reply

No. Do not use Levitra in severe hepatic impairment. Vardenafil has not been evaluated there.

Irena D. Child-Pugh B. Is 20 mg the ceiling?

Vault reply

Child-Pugh B opens at 5 mg and must not go past 10 mg. After 10 mg, Cmax was 130 percent higher and AUC 160 percent higher than in healthy controls. Twenty milligrams is off that chart.

Seth M. Mild liver test bumps. Cut to 5 mg?

Vault reply

On Child-Pugh A, 10 mg raised Cmax 22 percent and AUC 17 percent. No dose cut is written for mild impairment. The clinician still picks the start. Most men start at 10 mg.

Before you start, stop, or change any medicine, speak with your prescriber or pharmacist - they hold your chart, this vault card does not. Open the vault disclaimer.