01What this vault's 25-50 mg still inherits
The counselling talk for 25 mg or 50 mg still uses a roughly 4-hour working window and a plasma half-life near 4 hours.
When to swallow sits on about one hour, window to 4. The sildenafil 25-50 mg vault keeps 25-50 mg as the featured start.
02Why the tablet was 100 mg in that room
The duration arm used 100 mg. That is the labelled ceiling, not the usual start. Most men still begin at 50 mg. 25 mg is the consider-start on the same insert.
Do not read 13 of 16 as a 50 mg promise. It is a 100 mg clock in a small crossover.
03Why later hour studies stay off this page
Other protocols looked at 8 hours and 12 hours after 100 mg. Those n/N cards are a different job. Gluing them here would mix two clocks.
If a couple is planning past midnight after an early swallow, that is a class conversation, not a second Eardley table.
04How 13 of 16 compared with placebo
Five of 16 men also met the responder rule on placebo at 4 hours. The labelled claim is the difference, not a 100 percent night. Arousal was part of the method.
This page will not add a second hour's n/N from a later protocol.
05When the 4-hour counselling talk is enough
For a 50 mg start, plan the hour, keep the night inside a 4-hour band, and do not stack. Eardley's 13 of 16 is why clinicians still mention 4 hours as a working mark on the 100 mg ceiling tablet.
Once per day still caps the calendar. A late 4-hour attempt is not a second 50 mg.
06What Eardley counted at 4 hours
When visual sexual stimulation started 4 hours after dosing, 13 of 16 men on sildenafil met the responder definition versus 5 of 16 on placebo (Eardley et al., Br J Clin Pharmacol 2002). n/N and the percent sit in that one sentence: 13/16 (81%) versus 5/16 (31%).
Median duration of grade 3 or 4 erections at that mark was 5.0 minutes on sildenafil versus 0 minutes on placebo.